Match Summary
The Red Devils' disappointing recent struggles persisted at Leeds' fortress, but head coach the Portuguese tactician had Matheus Cunha to thank for the team not suffering even more damage against Leeds.
Dominic Calvert-Lewin directed a first-half effort against the woodwork for the confident hosts before the American midfielder applied a cool finish with a driven, 62nd-minute shot.
At that stage, Amorim was under intense scrutiny after his side had failed to beat struggling Wolves at Old Trafford earlier in the week.
Nevertheless, against opponents who had two days less to recover, Cunha restored parity three minutes later when he latched onto a pass from substitute the Dutchman and slid a shot underneath advancing Leeds goalkeeper Lucas Perri.
It was only the South American's fourth goal since his big-money summer move and came at a time when Amorim is without several key attacking players due to a combination of injury and national team commitments.
Not that Leeds to sympathise with that given their own tight schedule.
Noah Okafor forced a diving save out of visiting goalkeeper Senne Lammens with a audacious overhead kick, and visiting heads were in hands when the Slovenian striker, who is struggling to make an impression, turned his teammate's cut-back wide from six yards out.
The goalscorer, who had a goal disallowed for offside much earlier in the contest, also blasted against a post late on.
The draw prolongs the home side's unbeaten run to seven games, their longest such streak since 2001, and takes them eight points clear of the relegation zone.
For the Manchester United though, it was yet another chance to move into the Champions League places, albeit only for a short time, squandered.
With the AFCON reaching its knockout phase, the United coach could be forgiven for hoping the participating nations make a swift exit.
Existing injuries to skipper Bruno Fernandes and England international Mason Mount only heightened the impact the unavailability of other forwards is having on the team's options.
It's not that the missing pair are the answer to all of United's problems. After all, they were part of the side that suffered poor results earlier in the season.
But without them, the boss has few attacking options.
He clearly does not have full faith in teenager Shea Lacey or the much more experienced Zirkzee, even though the Dutch forward delivered the through ball for the equaliser almost instantly after his arrival as a replacement.
That leaves Cunha, who has now scored three goals in five games, and others operating out of their natural positions, alongside Sesko.
On this showing, the big-money frontman looks similar to previous underwhelming signings, lacking in confidence and assurance in front of goal.
Sesko's failure to turn home Zirkzee's cross means it is now nine games without a goal for the young striker.
After thrilling victories in their last few home games, the arrival of their fiercest rivals to Elland Road was a bit drab affair.
True, there were moments of typical fervor, but the intimidating edge was not as pronounced as in previous fixtures.
Leeds' fans were more concerned about their side's struggle to get sustained possession in dangerous areas for any prolonged period.
The striker's header that struck the post was an isolated moment of threat in a congested first half.
It still felt as though the hosts were finding it tough when a mistake opened the door for the opener.
Ever so briefly, Leeds' ecstatic fans thought they were about to secure a coveted win against their old foes.
However, there is a much bigger picture for Daniel Farke and Leeds to deal with.
When they suffered a difficult run of form earlier in the season, many thought about the manager's future.
In contrast, he is now overseeing clear progress.
The job is not done yet but step by step, Leeds are getting closer to achieving their top-flight status.
Leeds have a top-flight trip to Newcastle in midweek, followed by the start of their FA Cup campaign next weekend. Manchester United face a Premier League trip to Turf Moor before also entering their FA Cup journey with a Old Trafford tie.
A passionate esports journalist and community manager with over a decade of experience in the gaming industry, specializing in UK esports coverage.